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We use cell suspensions containing stem cells, in comprehensive treatment of patients with nonspecific ulcerative colitis and Crohn’s disease. Transplantation of stem cells is effective in cases of both acute and chronic forms of nonspecific inflammatory bowel diseases of all severity grades, including severe course.

Indications for use of stem cells are as follows:

• progressing disease unresponsive to conservative therapy for 2 weeks;

• presence of extraenteric complications;

• impossibility to carry out surgical intervention due to patient’s severe condition resulting from anemia, hypoproteinemia, profound metabolic disorders;

• exhaustion;

• difficulty finding the same blood group for transfusion, or same group incompatibility between a donor and a recipient detected through compatibility testing.

The table below presents main clinical criteria of treatment efficacy based on 16 years of experience in patients with nonspecific ulcerative colitis and Crohn’s disease.


Symptoms

% of patients experiencing the symptom

Prior to
transplantation

Time after transplantation

1 month

6 months

Daily stool frequency

3 and less

11.1

85.2

77,8

4 and more

88.9

14.8

22,2

Stool consistency 

formed

3.7

74.1

66,7

loose or doughy

96.3

25.9

33,3

Pathological admixtures in feces:

mucus 

81.5

40.7

29,6

blood

88.9

37.0

14,8

purulence

14.8

0.0

3,7

Tenesmus

66.7

14.8

18.5

Abdominal pain

85.2

18.5

29.6

Elevation of body temperature

48.1

11.1

18.5

After the stem cell treatment, red blood cell count is restored and the haemoglobin level is normalized in patients. Transplantation of stem cells restores immunocompetency and hinders the progression of an autoimmune process (mechanism of development of the illness), allowing to attain prolonged remission. Remission in patients with nonspecific ulcerative colitis lasts, on the average, for 12–15 months, and in patients with Crohn’s disease – for up to 2.5–3 years.